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TriMix FAQs

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Trimix "Causes" erections to happen,

Oral ED medications "Help" erections happen

Trimix is an injectable ED medication

Trimix has been the go to medication when Viagra or Cialis doesn't work  ( PDE5 inhibitors)

History: Created and in use since 1983.

How does Trimix work to produce an erection?

Trimix induces an erection by relaxing the smooth muscles and widening the blood vessels in the penis. They are not dependent on nerve stimulation.

Does a tolerance  develop creating a need for increasing dosage?  This can happen over time. Aging also influences the need for stronger formulas.

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Trimix Storage

Keep Refrigerated. It begins to lose it's potency after 6-8 weeks. .

Storing frozen, membership reports having stored Trimix frozen 6-9 months after which it began to lose potency. 

How you thaw matters. Recommended: Rubbing between your palms and shaking to break up the ice will thaw a vial in about 3-5 minutes without risking excess heat exposure


Thawing & Freezing repeatedly is not recommended. Cycling often between frozen and liquid form may degrade it's stability and potency.

Thawing in water is Not Recommended

Other options

1) Putting some pre-measured syringes in the refrigerator and freezing the difference (however the syringe plastic does not freeze well) 

2) Buying sterile vials online and refrigerating some of them and freezing the difference.  

(Also purchasing in larger 10ml vials and then storing, provides for significant quantity discount & shipping savings)

Does the medication lose potency over time even if stored correctly? Yes

  • It will Begin to lose it's strength after 60-90 days in a refrigerator  

  • Frozen it can last for six months (or more) 

  • Also cycling between freezing and thawing may degrade it's strength

Caution Advisory | Contamination Possibilities

The following indicates contamination of your injectable medication

(Trimix, Quadmix, Bimix, etc...) and Should Not be Used 

  • Medication with anything floating in the vial

  • Medication that is has discoloration, should be clear

Usage of contaminated medication can be very harmful!

Do not use.

Trimix Usage

Trimix produces erections generally  lasting  1-4 hours

Trimix produces erections generally regardless of your circumstance, including too much alcohol, too much caffeine , too much etc...  

Extended erections can be quite hazardous and dangerous to penis health. Penises need fresh blood flow after a while and TriMix inhibits this. 

How to Inject Trimix Videos

TriMix Injection Techniques videos

Click Here for Trimix Videos | Opens New Window

Trimix  Efficacy

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How to Open Trimix Vials

Select 2nd Video : "What Trimix Is and How to Self-Inject TriMix Medication (with Step-by-Step Instructions)" remove cap starts at: 00:55

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What is Trimix:

Papaverine, Phentolamine and (PGE)Alprostadil

Papaverine: is a vasodilator: produces an erection by allowing for increased blood flow to the penis. (Brings blood into the penis)

Phentolamine: is an Alpha Blocker: induces an erection by relaxing and dilating the blood vessels of the penis, as well as by elevating cardiac output (Makes more room to store more blood )

PGE: (Alprostadil): known as Prostaglandin in the body:  allows for more blood into the penis and lets less blood out by relaxing the penis's blood vessels and dilating cavernosal arteries (Retains blood in the penis )

The ratio of the mixtures of the the three come in many varieties to suit patient needs.  

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What is Quadmix:

Trimix  plus Atropine

QuadMix uses the same ingredients as TriMix , plus the addition of Atropine

Atropine:  Atropine sulfate works by inhibiting the nervous system receptors that control smooth muscle relaxation. Keeps the erection muscles stiff by not letting them relax. 

QuadMix is usually prescribed for patients for whom Trimix does not work sufficiently well

What is Bimix:

Trimix minus PGE(alprostadil)

Papaverine and Phentolamine Only

BiMix is often prescribed for patients for whom  find Trimix, in particular Alprostadil, painful

What is Forskolin:

a Vasodialator

Forskolin is sometimes used in lieu of Alprostadil (PGE)

Patients experiencing Extreme Forms of pain ( severe ache) from Trimix/Quadmix  sometimes find satisfaction with Forskolin substituting for PGE.

What is VIP:

a Vaso-Intestinal Peptide

The combination of VIP and Phentolamine is another safe and effective means of treating ED.

VIP has a potent effect on the veno-occlusive mechanism, but little effect on arterial inflow, whereas phentolamine increases arterial blood flow with no effect on the veno-occlusive mechanism

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Trimix Injection Technique | Best Practices

  1. Alternate sides of injection to avoid scaring tissue

  2. Lay your penis flat out and fully extended (but soft)

  3. Point needle to the center, not up or down

  4. Avoid veins

  5. Target the area 1 inch up from the base between 1 to 3 o'clock ( or 9 to 11)

  6. Must use a 90 degree angle to avoid bending the needle. You are injecting at a right angle to a curved surface and it is easy to bend & miss without knowing.

  7. Use a 1/2 inch length needle - it's needed to reach into the cavernosum

  8. Push needle completely flush to the skin

  9. Work the plunger a few times before filling syringe to insure it is not sticky

  10. Don't force the plunger. If it is really difficult to push, then you should start over making sure the needle is in properly

Trimix Dosing 

  • The typical average recommended dose is 20 units (.2ml)

        , patients often use more and/or less for their individual needs. 

  • Initially use 1/2  ie: .1ml or 10 units for the very first time ...just help gauge your requirements

  • It is recommended to skip a day between usage. ie: not more than every other day 

How to Inject Trimix    

Compliments of the Department of Urology, University of California, San Francisco

Filling the syringe,  Pull the plunger  down to the 1.0 cc mark (drawing in air) and then push the needle through the rubber stopper. Depress plunger, pushing the air into the vial before withdrawing the medication.

This makes withdrawing the medication easier by relieving an air vacuum

Where to InjectAim for the Corpora Cavernosa (as shown)

                             Avoid veins

                             1 inch up from the base

                             Angle to the Center     

Penis Structure Cavernosa
Where to Inject Trimix

Inject one inch up from the base - between   1 - 3  or  9 - 11 o'clock

Needle MUST be angled properly to the center of the penis as shown. 

Use a 1/2 inch long needle to reach all the way into the Corpora Cavernosa

Injection Sites.png

Q) What should I feel when I inject? 

A) Very light discomfort, as there are few nerve endings for pain in this area. The needle should be pushed firmly until it is fully in the penis, slight resistance may be felt.

If a lot of resistance is felt on the plunger then you may need to withdraw the needle and reinsert it in another suggested place. The plunger should depress quite easily. Do not inject if the resistance is strong.

Q) If I don't get any response to an injection can I follow up with another injection maybe to a different side of the penis and perhaps using a smaller dose? 

A) Not recommended, as the first injection went somewhere, and will be absorbed. A second dose may have a cumulative affect resulting in too much medication. The next time you inject (on another day) do it on the other side of the penis.

Q) What's the best way to hold the penis for the injections? 

A) Ideally you need a flat surface to inject (minimal wrinkles) you may wish to pull the penis to full length and let it relax and then inject.

Trimix Auto-Injectors

Also available are injectors that allow a user to press a pen-like device up to their skin,

press a button and it will automatically insert needle and medication for you.

Some users like this, some do not as one loses active control of pressure of the needle and to a degree the depth of the injection. Auto-injectors are used for a large variety of medications and injection sites (tummy, thigh, etc...)

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Anchor 1 Reversal
Extended Erections & Erection Reversal

Trimix Reversal

Phenylephrine: Erection Reversal

  • Use only when needed (after about 4 hours of sustained erection)

  • Not recommended: using Phenylephrine every time just to "knock down" your erection can result in other issues

  • Waiting longer than 4 hours may negatively affect your results with Phenylephrine

  • Dose yourself with .5 ml (50 units on the syringe),  keep repeating every 5-10 minutes until the erection is lost

  • Inject into your penis in the same method as Trimix

Liquid Phenylephrine is strongly recommended for those with any blood pressure or heart issues

Phenylephrine Reversal

Phenylephrine is a potent vasoconstrictor.  Inject 100-500 mcg <micrograms> (0.1 ml - 0.5 ml) into the penis cavernosa. Repeat every 5-10 minutes and/or up to  1,000 mcg (1 ml) until your erection is gone.


After injection, massage the penis (the corpora cavernosa) to facilitate drug distribution.

Lower volumes should be used in patients with severe cardiovascular disease

Trimix and Sudafed for Erection Reversal

Sudafed and Benadryl  can be used reduce a prolonged erection.  However

NOT Recommended for those with any blood pressure or heart issues (use Liquid Phenylephrine)

Memorial Sloan hospital instructs:  take 4 (30 mg) tablets of pseudoephedrine HCl (Sudafed) of the "Fast Acting" variety Only, not the  "Time Release":  via Memorial Sloan

How well does Trimix work? 

Will it work for you?      Yes

Caveat:   There is an apparent consensus of around 90% efficacy.

ie: It works for around 90% of the people who tried it

Research white paper summary:

Combination therapy first was introduced in 1991 by Bennett and coworkers[2] with a reported success rate of 92%


Efficacy for this treatment option is as high as 87% to 93% (Linet &. Ogring, 1996
by JA Albaugh - ‎2006 - ‎Cited by 11 - ‎Related articles

(KSSMA) Guideline on Erectile Dysfunction - :: WJMH :: The World ...
by JK Ryu - ‎2013 - ‎Cited by 18 - ‎Related articles

Aug 31, 2013 - Trimix was shown to have a better efficacy rate (92%) and less pain, but a higher risk of prolonged erection and cavernous fibrosis compared to ...

How many Doses are in a 5ml Vial of Trimix

20 - doses typically depending on dose size (which means your mileage will vary  ie:  15 -30 )

A small vial = 5ml

A full syringe  equals 1.0 ml  (A vial = 5 Full syringes)

A typical syringe is marked with 100 units (0.01ml x 100)  

A typical Dose (for example)  is 0.20ml. (ie: 20 units on the syringe)

That means there are around 25 doses in a vial using  0.20ml as a dose
0.20ml dose
x 25 uses = 5ml

Trimix Purchase Caution

Be advised, a black market for the prescription treatment has developed, and Trimix is being sold and administered without the supervision of a physician. You can guess the consequences: Men are being given excessive doses of Trimix, and are suffering the complications of priapism, landing in emergency rooms. Bottom line: Using Trimix outside of medical supervision is a very high risk strategy.

Additionally less than sterile development can lead to poor quality and obvious risks of dangerous injections and infections. Buy quality from a USA accredited pharmacy. Look for FDA accreditation or ACHC (Accreditation Commission for Health Care).   

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Trimix Risks

There is always risk to whatever medication you take.

The big ones for Trimix you may already know:

Extended erections:  Penises need blood, erections inhibit blood flow. Cut blood flow off long enough
and it becomes an issue.  This is THE reason to have reversal medication available (phenylephrine)

Peyronies disease:   tissue hardening, especially at injection sites, can cause curvature over time. Making it a really good idea to alternate injection sites.

Which Trimix Formula is right for you?

There is no test that can be given to determine the perfect formula for anyone. 
Looking at your medical profile and using past experience provides the best guidance.

Of paramount importance, is getting the formula right without it being too strong as the risk of having an erection for too long and having to go to the ER  is absolutely real and must be considered by the user.

When a persons profile is outside a "typical profile" it can be really difficult to say with any certainty what exactly will be right. Medical history, health and ED status must all be considered.

For those reasons there may be some trial and error before the formula is  appropriately "dialed in" for the individual.

Travel and Trimix

Traveling with Trimix by plane is often asked about

The following is a summary of excerpts obtained from (our preferred source of ED info)

The TSA agents are apparently accustomed to seeing medication on ice.

Some Best Practices

  • Place already frozen Trimix in a thermos with ice - or

  • Purchase an insulin travel container

  • Take the written prescription with you 

Excellent ideas: 

  • Laminate/clear-tape the script to keep it readable

  • Attach it to the cooler / pouch / travel container directly (keep a copy on yourself)

The travel pouch "FRIO" has gotten rave reviews.

Requires no ice or freezing, soak pouch in water, let dry, stays cool for a couple days
No electricity needed, never gets cold - but stays cool

Click HERE for More Info and use code "RBC5" for a 5% discount at checkout

Some Excerpts:

Taking Trimix to the Caribbean is no big deal. I fly to the Caribbean twice a year. Usually I just throw a small vial of the Trimix into a 12- or 16-ounce coffee thermos. I fill it with ice and away I go. When I first started this I pulled a TSA officer aside and explained the thermos, ice and medicine.

"No problem," he said. The thermos passed through the x-ray just fine and there were no further questions. Inside the thermos the temperature remains cold until I clear customs in the Dominican Republic or wherever in the Caribbean I'm traveling.

Sometimes I would just seal the thermos tight and just throw it into my checked baggage. Never had a problem with any TSA or Custom inspections. But I stopped doing that because I feared the one-in-a-million chance my bag might be lost or stolen. Then I'd be in the DR with no juice and no way to get any until I returned to the states. That obviously would be a bummer.

Also I have a Frio. It's a very small case made for keeping insulin cold as you travel. It's about the size of a wallet and there is no liquid inside. I like it a lot. Sometimes I use the Frio instead of the thermos.

The bottom line is don't even fret about taking your juice with you.

If you want added piece of mind regarding TSA or Customs take a copy of your prescription with you.


For travel via aircraft, I staple a small laminated copy (the prescription label) of my script to the pouch. TSA and customs inspectors regularly see diabetics and other people traveling with injectables, so they're not automatically alarmed at encountering syringes in luggage. But at least once, my attached label simplified and eased an encounter with a TSA guy.


I think having the prescription label attached to the syringe packet simplified the process and minimized the hassle.

I also sometimes use a small coffee thermos with ice to keep the juice cold. Never any problems with TSA, including sending the thermos with ice through the x-ray.


I have used the Frio many, many times with no problems. The Frio is really just a pouch with a small pocket to fit the trimix. You remove the pocket and soak it in water to activate some crystals that will keep the Trimix at an acceptable temperature for more than a day. The only problem with the Frio is that the Trimix won't seem cold to the touch of your fingers the way it would if you had it soaked in ice. However, I used the Frio once on a trip that lasted more than a week with no problems.

My favorite solution of the two is the thermos, however.

I have passed a thermos with Trimix and ice through airport x-ray machines with no problems. And just to make sure I checked with TSA before entering security. "No problem," the TSA agent said.

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