Trimix Injection Technique | Best Practices
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Alternate sides of injection to avoid scaring tissue
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Lay your penis flat out and fully extended (but soft)
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Point needle to the center, not up or down
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Avoid veins
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Target the area 1 inch up from the base between 1 to 3 o'clock ( or 9 to 11)
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Must use a 90 degree angle to avoid bending the needle. You are injecting at a right angle to a curved surface and it is easy to bend & miss without knowing.
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Use a 1/2 inch length needle - it's needed to reach into the cavernosum
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Push needle completely flush to the skin
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Work the plunger a few times before filling syringe to insure it is not sticky
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Don't force the plunger. If it is really difficult to push, then you should start over making sure the needle is in properly and not bent.
How to Inject Trimix
Compliments of the Department of Urology, University of California, San Francisco
Filling the syringe, Pull the plunger down to the 1.0 cc mark (drawing in air) and then push the needle through the rubber stopper. Depress plunger, pushing the air into the vial before withdrawing the medication.
This makes withdrawing the medication easier by relieving an air vacuum
Where to Inject. Aim for the Corpora Cavernosa (as shown)
Avoid veins
1 inch up from the base
Angle to the Center

Where to Inject Trimix
Inject one inch up from the base - between 1 - 3 or 9 - 11 o'clock
Needle MUST be angled properly to the center of the penis as shown.
Use a 1/2 inch long needle to reach all the way into the Corpora Cavernosa

Q) What should I feel when I inject?
A) Very light discomfort, as there are few nerve endings for pain in this area. The needle should be pushed firmly until it is fully in the penis, slight resistance may be felt.
If a lot of resistance is felt on the plunger then you may need to withdraw the needle and reinsert it in another suggested place. The plunger should depress quite easily. Do not inject if the resistance is strong.
Q) If I don't get any response to an injection can I follow up with another injection maybe to a different side of the penis and perhaps using a smaller dose?
A) Not recommended, as the first injection went somewhere, and will be absorbed. A second dose may have a cumulative affect resulting in too much medication. The next time you inject (on another day) do it on the other side of the penis.
Q) What's the best way to hold the penis for the injections?
A) Ideally you need a flat surface to inject (minimal wrinkles) you may wish to pull the penis to full length and let it relax and then inject.
Trimix Auto-Injectors
Also available are injectors that allow a user to press a pen-like device up to their skin,
press a button and it will automatically insert needle and medication for you.
Some users like this, some do not as one loses active control of pressure of the needle and to a degree the depth of the injection. Auto-injectors are used for a large variety of medications and injection sites (tummy, thigh, etc...)