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What is Trimix:

Papaverine, Phentolamine and (PGE)Alprostadil

Papaverine: is a vasodilator: produces an erection by allowing for increased blood flow to the penis. (Brings blood into the penis)

Phentolamine: is an Alpha Blocker: induces an erection by relaxing and dilating the blood vessels of the penis, as well as by elevating cardiac output (Makes more room to store more blood )

PGE: (Alprostadil): known as Prostaglandin in the body:  allows for more blood into the penis and lets less blood out by relaxing the penis's blood vessels and dilating cavernosal arteries (Retains blood in the penis )

The ratio of the mixtures of the the three come in many varieties to suit patient needs.  

What is Quadmix:

Trimix  plus Atropine

QuadMix uses the same ingredients as TriMix , plus the addition of Atropine

Atropine:  Atropine sulfate works by inhibiting the nervous system receptors that control smooth muscle relaxation. Keeps the erection muscles stiff by not letting them relax. 

QuadMix is usually prescribed for patients for whom Trimix does not work sufficiently well

What is Bimix:

Trimix minus PGE(alprostadil)

Papaverine and Phentolamine Only

BiMix is often prescribed for patients for whom  find Trimix, in particular Alprostadil, painful

What is Forskolin:

a Vasodialator

Forskolin is sometimes used in lieu of Alprostadil (PGE)

Patients experiencing Extreme Forms of pain ( severe ache) from Trimix/Quadmix  sometimes find satisfaction with Forskolin substituting for PGE.

What is VIP:

a Vaso-Intestinal Peptide

The combination of VIP and Phentolamine is another safe and effective means of treating ED.

VIP has a potent effect on the veno-occlusive mechanism, but little effect on arterial inflow, whereas phentolamine increases arterial blood flow with no effect on the veno-occlusive mechanism

https://pubmed.ncbi.nlm.nih.gov/10233493/

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How to Open Trimix Vials

Select 2nd Video : "What Trimix Is and How to Self-Inject TriMix Medication (with Step-by-Step Instructions)" remove cap starts at: 00:55

Trimix Dosing 

  • The typical average recommended dose is 20 units (.2ml)

        , patients often use more and/or less for their individual needs. 

  • Initially use 1/2  ie: .1ml or 10 units for the very first time ...just help gauge your requirements

  • It is recommended to skip a day between usage. ie: not more than every other day 

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How well does Trimix work? 

Will it work for you?      Yes

Caveat:   There is an apparent consensus of around 90% efficacy.

ie: It works for around 90% of the people who tried it

Research white paper summary:

Combination therapy first was introduced in 1991 by Bennett and coworkers[2] with a reported success rate of 92% 
https://www.medscape.com/viewarticle/436979

 

Efficacy for this treatment option is as high as 87% to 93% (Linet &. Ogring, 1996 
https://www.suna.org/download/members/unjarticles/2006/06dec/449.pdf
by JA Albaugh - ‎2006 - ‎Cited by 11 - ‎Related articles


(KSSMA) Guideline on Erectile Dysfunction - :: WJMH :: The World ...   https://wjmh.org/DOIx.php?id=10.5534/wjmh.2013.31.2.83
by JK Ryu - ‎2013 - ‎Cited by 18 - ‎Related articles

Aug 31, 2013 - Trimix was shown to have a better efficacy rate (92%) and less pain, but a higher risk of prolonged erection and cavernous fibrosis compared to ...

How many Doses are in a 5ml Vial of Trimix

20 - doses typically depending on dose size (which means your mileage will vary  ie:  15 -30 )

A small vial = 5ml

A full syringe  equals 1.0 ml  (A vial = 5 Full syringes)

A typical syringe is marked with 100 units (0.01ml x 100)  

A typical Dose (for example)  is 0.20ml. (ie: 20 units on the syringe)

That means there are around 25 doses in a vial using  0.20ml as a dose
0.20ml dose
x 25 uses = 5ml

Trimix Purchase Caution

Be advised, a black market for the prescription treatment has developed, and Trimix is being sold and administered without the supervision of a physician. You can guess the consequences: Men are being given excessive doses of Trimix, and are suffering the complications of priapism, landing in emergency rooms. Bottom line: Using Trimix outside of medical supervision is a very high risk strategy.

Additionally less than sterile development can lead to poor quality and obvious risks of dangerous injections and infections. Buy quality from a USA accredited pharmacy. Look for FDA accreditation or ACHC (Accreditation Commission for Health Care).   

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Trimix Risks

There is always risk to whatever medication you take.

The big ones for Trimix you may already know:

Extended erections:  Penises need blood, erections inhibit blood flow. Cut blood flow off long enough
and it becomes an issue.  This is THE reason to have reversal medication available (phenylephrine)

Peyronies disease:   tissue hardening, especially at injection sites, can cause curvature over time. Making it a really good idea to alternate injection sites.
 

Which Trimix Formula is right for you?

There is no test that can be given to determine the perfect formula for anyone. 
Looking at your medical profile and using past experience provides the best guidance.

Of paramount importance, is getting the formula right without it being too strong as the risk of having an erection for too long and having to go to the ER  is absolutely real and must be considered by the user.

When a persons profile is outside a "typical profile" it can be really difficult to say with any certainty what exactly will be right. Medical history, health and ED status must all be considered.


For those reasons there may be some trial and error before the formula is  appropriately "dialed in" for the individual.
 

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